| Package | Dosage | Price | Price per Dose | |
|---|---|---|---|---|
| Dosage: 25mg | ||||
| 120 pill | 25mg | NZD259.89 | NZD2.17 | |
| 90 pill | 25mg | NZD205.04 | NZD2.27 | |
| 60 pill | 25mg | NZD140.66 | NZD2.34 | |
| 30 pill | 25mg | NZD73.90 | NZD2.48 | |
| Dosage: 50mg | ||||
| 270 pill | 50mg | NZD572.25 | NZD2.12 | |
| 240 pill | 50mg | NZD519.79 | NZD2.17 | |
| 120 pill | 50mg | NZD305.19 | NZD2.55 | |
| 90 pill | 50mg | NZD267.04 | NZD2.96 | |
| 60 pill | 50mg | NZD185.97 | NZD3.10 | |
| 30 pill | 50mg | NZD97.74 | NZD3.24 | |
Azathioprine Description
Understanding Azathioprine
Azathioprine is a potent immunosuppressive medication commonly prescribed to manage a variety of autoimmune conditions and prevent organ transplant rejection. Its primary function is to inhibit the growth of certain cells within the immune system, effectively reducing inflammation and immune response. This medication has been in use for many years and has become a cornerstone treatment for conditions such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, and in post-transplant therapy.
How Azathioprine Works
Azathioprine is a prodrug, meaning it is converted into an active form called 6-mercaptopurine in the body. This active metabolite interferes with DNA synthesis, particularly targeting rapidly dividing cells, including immune cells called lymphocytes. By suppressing lymphocyte proliferation, azathioprine diminishes the immune response responsible for attacking the body's tissues in autoimmune diseases. Additionally, this mechanism helps prevent the rejection of transplanted organs, making it a valuable drug in transplant medicine.
Advantages of Using Azathioprine
One of the main benefits of azathioprine is its effectiveness in reducing disease activity and maintaining remission in chronic autoimmune disorders. Patients often experience fewer flare-ups and an overall improvement in quality of life when on proper therapy. For transplant recipients, azathioprine plays a crucial role in long-term organ preservation, helping to prevent rejection episodes. The medication is generally considered cost-effective compared to newer immunosuppressants and has a well-established safety profile when monitored appropriately.
Potential Side Effects and Risks
Despite its benefits, azathioprine can cause side effects. Common adverse reactions include nausea, vomiting, loss of appetite, and fatigue. More serious issues may involve bone marrow suppression, leading to low blood cell counts that can increase infection risk or cause bleeding and anemia. Liver enzyme abnormalities and hypersensitivity reactions are also possible. Due to these risks, regular blood tests are essential to monitor blood counts and liver function during treatment. Patients with certain genetic mutations may be at higher risk for toxicity, making genetic testing before starting therapy advisable.
Considerations and Precautions
Before initiating azathioprine therapy, healthcare providers carefully evaluate the patient's overall health and potential contraindications. Patients should inform their doctor of any existing liver or kidney issues, infections, or other medications they are taking. Pregnant and breastfeeding women must discuss the risks, as azathioprine can affect fetal development and passes into breast milk. It is also crucial to adhere strictly to the prescribed dosage and schedule to minimize side effects and maximize efficacy. Close monitoring during treatment helps detect any adverse effects early and allows for appropriate adjustments.